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For example, according to the firms investigation reports, some batches were rejected because they failed to meet blend uniformity or dissolution specifications. However, SOMA should only be used for short periods of 2 to 3 weeks because the effectiveness of prolonged use has not yet been proven. Recent animal studies conducted under the directive of the National Institute on Drug Abuse NIDA indicate that subjective effects of carisoprodol may be similar to other central nervous system depressants such as meprobamate, pentobarbital and chlordiazepoxide and it possesses rewarding effects.